Triple antibiotic paste is an endodontic preparation that is ideal for treating primary teeth with a pulpotomy to avoid tooth extraction. This procedure using a mix of antibiotics minimizes instrumentation and is referred to as an endodontic regenerative procedure (ERP). The treatment technique is sometimes called Lesion Sterilization and Tissue Repair (LSTR). With LSTR, damaged tissues can be repaired through the disinfection of lesions achieved with triple antibiotic paste. This method has been demonstrated to produce a greater increase in dentin wall thickness and improved functional development of the pulp-dentin complex.
Three Effective Antibiotics in One
There are a variety of bacteria that can be present in an infection and some may be resistant to certain antibiotics. A single antibiotic used alone is not likely to provide complete sterilization. By combining three different antibiotics together for LSTR, the multiple types of bacteria that may be present in a root canal infection can be eliminated. The MP paste made with macrogol and propylene glycol is an excellent vehicle to carry the antibiotics into the dentin to kill the bacterial lesions.
Triple Antibiotic Paste Formulations
There are two formulations for triple antibiotic paste that we make that are both effective. The 3Mix MP is the “original” formulation but we now offer an alternate formulation based on requests from dentists who use the product. Each order of triple antibiotic paste comes packaged in two luer-lock syringes for mixing the antibiotic powder and the MP paste.
3Mix MP
Metronidazole 33%, Minocycline 34%, and Ciprofloxacin 33% with a Macrogol and Propylene Glycol (MP) Paste
In one study, 83 out of 87 patients showed improvement in symptoms after one application of 3Mix paste. After treatment, gingival swelling and fistulae disappeared along with pain and teeth functioned normally. Mechanical procedures were avoided and only one office visit was required for the majority of patients. Although this particular study involved primary teeth, 3Mix can effectively eliminate bacteria from permanent teeth as well.
3Mix MP Alternate
Metronidazole 33%, Clindamycin 34%, and Ciprofloxacin 33% with a Macrogol and Propylene Glycol (MP) Paste
This paste is based on the 3Mix MP formula but replaces minocycline with clindamycin. Clindamycin is used as an alternative antibiotic to prevent possible tooth staining with minocycline.
Prescription Form
Please email us at Info@ParkCompounding.com or call us at (805) 497-8258 for the prescription form.
Research
Instructions
Click to download Triple Antibiotic Paste mixing instructions.
