Nitroglycerin Ointment available in 0.125%, 0.2%, and 0.4% strengths

This compounded ointment is used to treat anal fissures. Nitroglycerin is in the nitrate family and works to dilate blood vessels, increasing blood flow to the anal fissure. It also reduces pressure in the internal anal sphincter, which decreases pain and further facilitates healing.

The dosage is usually a small, pea-sized dot of ointment applied around the anal opening two to three times daily, as well as before and after bowel movements.

Nitroglycerin side effects can include headache and low blood pressure. Headaches,while common, are generally mild. They usually last less than 30 minutes, and resolve after two weeks of nitroglycerin use. Dizziness is another possible side effect. Patients should sit or lie down to apply the ointment, and should sit or stand up slowly.

Articles

Treatment of Chronic Anal Fissure with Topical Nitroglycerin. – Annals of Coloproctology